Song Of All Nations : \b Or, She Had To Decline

https://digitalcommons.library.umaine.edu/mmb-vp/4052/thumbnail.jp

The Isle of Champagne

I\u27m Pommery 2nd The King [Verse 1, Pommery]I\u27m Pommery Second the King And this is the day of my birth.I\u27ve had so much to drink It has caused me to think that I govern the whole of the earth.I\u27m a man of the style that\u27s self-made. I started in life as a Prince.I\u27ve studied the ologies of all the colleges And I haven\u27t done anything since.[Chorus, Moet & Chandon with Tenors]I\u27m a man of the style that\u27s self made. I started in life as a Prince.I studied the ologies of all the colleges And I haven\u27t done anything since. [Verse 2, Pommery] I entered a college at ten And studied until quite a wreck. The professors all said That the brains in my head were so heavy they\u27d fracture my neck. At football I took the first prize. At billiards my shots were massé. I could translate from Plato about a potato Inquite a phenomenal way. [Verse 3, Pommery] At twenty I finished at school And then I was called to the throne. Though I\u27m King of the isle I don\u27t own a mile and whatever\u27s mine isn\u27t my own. It\u27s a terrible thing to be King. If your crown isn\u27t backed up by wealth. Oh Long Live the King is a sad thing to sing When your income consists of your health.O\u27er Hill and DaleO\u27er hill and dale, in rill and vale, all sing the gathering of grape and vine.We dance and sing the harvest in, The harvest of the bubbling new-made wine.O\u27er hill and dale, in rill and vale, All sing the gathering of grape and wine.We dance and sing the harvest in, the harvest of the new-made wine.O\u27er hill and dale, in rill and vale, On sunny mountain sides we roam.To strip the vines of juicy grapes and rare all and press without a thought of care. Then homeward bound our songs resound, Our hearts are ever light and gay.We\u27ve done now with the busy hours of day, The busy, busy hours of day..... Oh, Dream of Life[Priscilla] Oh, dream of life, forever rife, I\u27m glad and breathe once more. I know not how with awful stride We safely reached the shore. Oh, dreadful night, sad was our plight, We thought that all must die. Our sailors worked, no duty shirked, And each with each did vie. The dreadful waves o\u27er-whelmed us, all our efforts were in vain. We crashed upon the shore, Our ship was no more. How bright it all seems.I live once more. Ah! Oh, dream of life forever rife, I\u27m glad and breathe once more. I know not how with awful strife We safely reached the shore. Now escaped from the ocean, With what words of devotion. Saved from peril and pain, Ah! Saved from peril and pain. [Kissengen] (joins Priscilla on line five) Their efforts were in vain, yes all in vain. They crashed upon the shore, was seen no more. How bright all seems, She lives once more. Ah! Oh, dream of life, forever rife, She\u27s glad and breathes once more. She knew not how with awful strife They safely reached the shore. Now escaped from the ocean, with what words of devotion. Saved from peril and pain. Ah, she\u27s saved from peril and pain. [Chorus]Now escaped from the ocean, with what words of devotion. (Priscilla, Kissengen, and Chorus all start the following verses at the same time) [Priscilla] With hearts full of emotion, From peril and pain we\u27re saved. Ah! Saved from peril and pain. Ah! Saved from peril and pain. With hearts full of emotion, From peril and pain we are saved, yes saved.... [Kissengen] With hearts full of emotion, From peril and pain we\u27re saved. Ah! She\u27s saved from peril and pain. From peril they\u27re saved, yes saved.... [Chorus] With hearts full of emotion, From peril and pain we\u27re saved. Ah! Ah! Now escaped from the emotion, With what words of devotion. With hearts full of emotion, yes, saved.... The North Pole[Binnacle] Now we listen mates to a story of the sea--- [Soprano & Alto] Oh list to wanderer bold! [Binnacle] I\u27ll tell you of wonders happening to me. In the Arctic seas where the icebergs freeze And you shiver, shiver, shiver with the cold. [Soprano & Alto] Where the weather is fickle as a soft icicle And you shiver, shiver, shiver with the cold. [Binnacle] I sailed from the port of Milwaukee, To discover the old North Pole. We cleared Montana in the southern sea.And they blew Cape Horn when they summoned us to tea. That\u27s the truth upon my soul. [Soprano & Alto] That\u27s the truth upon his soul. [Binnacle] We passed over Niagara falls, Where the whales and the elephants roam. And the ship lay to off Kalamazoo, On a voyage to the Northern Pole. [Soprano & Alto] Then shout hurrah! for the sailor bold and the wonders he did see. But please explain why the ship lay to? [Binnacle] Why because she couldn\u27t lay three. [Verse 2]We sailed due north thro\u27 Kentucky\u27s mammoth cave--- [Soprano & Alto] Oh list to the wanderer bold! [Binnacle] We then was struck by a mighty tidal wave. And a herd of whales jumped up on the sails And hung by the yards a wagging of their tails. [Soprano & Alto] What a horrid herd of whales thus to hang upon the sails with a wagging, wagging, wagging of their tails. [Binnacle] We threw a rope round the old North Pole, Which stands on the lee of Maine. The ship got wrecked off that awful coast, We had nothing to eat but quail on toast. That mem\u27ry gives me pain. [Soprano & Alto] That mem\u27ry gives him pain. [Binnacle] We met a tribe of bunko men, Who captured ev\u27ry soul. But I made them grieve for I took French leave On a voyage to the Northern Pole. [Soprano & Alto] Then shout hurrah! for the sailor bold who was clever enough to vanish. But please explain why you took French leave? [Binnacle] Why because I couldn\u27t walk Spanish. No Mercy He Need Expect No mercy he need expect from these four elect, We’re done brown.For though he has been so slick, We’ll yet make him sick for his scurvy trick And his crown.There is no denying that we are rattled…About privileges for which we’ve but battled… And considerations we had thought settled, but ‘tis not the time to say sca—...For as conspirators we must dissemble, Put brakes on our feelings before King and QueenJust now with the spirit o’er all those assembled t’would folly be surely to say what we mean. Here’s to Old Champagne [Pommery]The best of friends must part, alas! I’ll now say adieu, I’ll now say adieu…And ev’ry swain and lass I’ll pledge in a final glass.Never again to see you more, no never again. For here I remain,... Though all of you depart… to some distant shore…I’ll continue to reign right here,And stick to my dear champagne.Then here’s to old champagne, champagne, champagne, champagne.A parting cup we’ll drain, we’ll drain, we’ll drain.Alone in my domain I’ll reign, I’ll reign.I’ll get an ever-lasting jag; then here’s to old champagne

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Burnout Among Surgeons in the UK During the COVID-19 Pandemic: A Cohort Study

BackgroundSurgeon burnout has implications for patient safety and workforce sustainability. The aim of this study was to establish the prevalence of burnout among surgeons in the UK during the COVID-19 pandemic.MethodsThis cross-sectional online survey was set in the UK National Health Service and involved 601 surgeons across the UK of all specialities and grades. Participants completed the Maslach Burnout Inventory and a bespoke questionnaire. Outcome measures included emotional exhaustion, depersonalisation and low personal accomplishment, as measured by the Maslach Burnout Inventory-Human Services Survey (MBI-HSS).ResultsA total of 142 surgeons reported having contracted COVID-19. Burnout prevalence was particularly high in the emotional exhaustion (57%) and depersonalisation (50%) domains, while lower on the low personal accomplishment domain (15%). Burnout prevalence was unrelated to COVID-19 status; however, the greater the perceived impact of COVID-19 on work, the higher the prevalence of emotional exhaustion and depersonalisation. Degree of worry about contracting COVID-19 oneself and degree of worry about family and friends contacting COVID-19 was positively associated with prevalence on all three burnout domains. Across all three domains, burnout prevalence was exceptionally high in the Core Trainee 1–2 and Specialty Trainee 1–2 grades.ConclusionsThese findings highlight potential undesirable implications for patient safety arising from surgeon burnout. Moreover, there is a need for ongoing monitoring in addition to an enhanced focus on mental health self-care in surgeon training and the provision of accessible and confidential support for practising surgeons

Fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin with gemtuzumab ozogamicin improves event-free survival in younger patients with newly diagnosed aml and overall survival in patients with npm1 and flt3 mutations

Purpose To determine the optimal induction chemotherapy regimen for younger adults with newly diagnosed AML without known adverse risk cytogenetics. Patients and Methods One thousand thirty-three patients were randomly assigned to intensified (fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin [FLAG-Ida]) or standard (daunorubicin and Ara-C [DA]) induction chemotherapy, with one or two doses of gemtuzumab ozogamicin (GO). The primary end point was overall survival (OS). Results There was no difference in remission rate after two courses between FLAG-Ida + GO and DA + GO (complete remission [CR] + CR with incomplete hematologic recovery 93% v 91%) or in day 60 mortality (4.3% v 4.6%). There was no difference in OS (66% v 63%; P = .41); however, the risk of relapse was lower with FLAG-Ida + GO (24% v 41%; P < .001) and 3-year event-free survival was higher (57% v 45%; P < .001). In patients with an NPM1 mutation (30%), 3-year OS was significantly higher with FLAG-Ida + GO (82% v 64%; P = .005). NPM1 measurable residual disease (MRD) clearance was also greater, with 88% versus 77% becoming MRD-negative in peripheral blood after cycle 2 (P = .02). Three-year OS was also higher in patients with a FLT3 mutation (64% v 54%; P = .047). Fewer transplants were performed in patients receiving FLAG-Ida + GO (238 v 278; P = .02). There was no difference in outcome according to the number of GO doses, although NPM1 MRD clearance was higher with two doses in the DA arm. Patients with core binding factor AML treated with DA and one dose of GO had a 3-year OS of 96% with no survival benefit from FLAG-Ida + GO. Conclusion Overall, FLAG-Ida + GO significantly reduced relapse without improving OS. However, exploratory analyses show that patients with NPM1 and FLT3 mutations had substantial improvements in OS. By contrast, in patients with core binding factor AML, outcomes were excellent with DA + GO with no FLAG-Ida benefit

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Gabriella : a lyric drama in one act / Italian libretto by Alfred Byrne and Fulvio Fulgonio ; the English version by Mowbray Marras ; the music composed by Emilio Pizzi ; vocal score.

Includes synopsis in English and Italian. --- Italian article "Opere nuove" and English text note by Giovanni Clerici tipped in Sibley Music Library copy; personal copy of Giovanni Clerici

Some words there are we fondly cherish, [first line]

Performers: Miss Grace CameronPiano and Voice (with lyrics